The Gold Standard in Aseptic Filling

Pharmaceutical Filling Machines – The BFS Advantage

As the inventor of Blow-Fill-Seal (BFS) technology, Rommelag delivers the safest, most efficient, and most flexible pharmaceutical filling machines. From ophthalmics to vaccines, our BFS process forms, fills, and seals containers in one automated step — eliminating contamination risks and streamlining production.

B Blow

Sterile polymer resin extruded into a mold to form the container.

F Fill

The container is filled with the sterile product immediately.

S Seal

The container is hermetically sealed – no exposure, no risk.

B

Blow

Sterile polymer resin extruded into a mold to form the container.

F

Fill

The container is filled with the sterile product immediately.

S

Seal

The container is hermetically sealed – no exposure, no risk.

Minimal Contamination Risk

In the enclosed BFS process, container molding, filling, and sealing occur in one automated step — unlike traditional multi-step methods with separate washing, sterilizing, and capping. This eliminates environmental exposure and human contact, making BFS recognized as an advanced aseptic process.

Proven & Compliant

Backed by 60+ years of pharmaceutical expertise, our bottelpack machines meet the industry’s strictest standards, including EU GMP Annex 1, and comply with regulations from EMA, FDA, Anvisa, and more.

Strategic Economic Value

Our compact filling machines cut capital costs by eliminating the need for washing, sterilizing, and capping equipment and by reducing cleanroom space. Operational costs stay low thanks to low energy use, minimal maintenance, lean staffing, and cost-efficient polymer granulate.

Resilient & Simplified Supply Chain

Produce primary packaging directly at the point of fill from medical-grade polymer resin – eliminating components such as vials, stoppers, and caps, while reducing supplier, transport, and storage needs.

Protection for Sensitive Products

Our enclosed BFS process enables safe filling of heat-sensitive products like biologics and vaccines without terminal sterilization. For extremely heat-sensitive products, our innovative coolBFS technology further minimizes heat exposure.

Flexible Container Design

Our BFS technology, offers unparalleled flexibility, enabling single-dose, multi-dose, and specialized container designs like Luer-Lock systems to meet diverse pharmaceutical applications.

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Ophthalmics

Sterile Blow-Fill-Seal ampoules made of high-quality, recyclable low-density polyethylene (LDPE) are the ideal primary packaging for ophthalmic products, suitable for both single and multiple use. They meet the highest standards in user-friendly handling, format flexibility, product protection, and comply with regulatory requirements such as USP <771>.

Unit-Dose (Typically 0.1-1ml)

Up to 33,300 ampoules per hour
Preservative-free
Easy-to-open twist-off cap
Easy to dispense

Multi-Dose (Typically 1-15ml)

Up to 12,000 ampoules per hour
With or without preservatives
Closable, tamper-proof closure

Injections

Our recyclable LDPE or polypropylene (PP) ampoules are engineered explicitly for small-volume injectables ranging from 1 to 20 ml. They enable filling even demanding pharmaceutical products with sensitivities to heat, light, or oxygen and fulfill regulatory requirements such as USP <790> and <1790>.

Up to 33,300 vented or 20,000 calibrated ampoules per hour
Luer connection for easy and safe use
Calibrated Luer ampoules collapse during the withdrawal process with the syringe, preventing air ingress and contamination.
Terminally sterilizable

Infusions

The unbreakable, lightweight, and terminally sterilizable BFS infusion bottles are the superior packaging choice for infusion products. They can be vented or unvented and feature an integrated suspension device for versatile use.

Up to 10,000 bottles per hour
Various container geometries in the 50-1000 ml range
Optimized for effective product withdrawal even without ventilation due to the collapsing design of the infusion bottle
Product withdrawal through caps with an infusion port (Euro head) or nipple head.

Inhalation Solutions

Pharmaceutical products used in inhalers or nebulizers are safely protected in sterile BFS ampoules. With a user-friendly twist-off cap and soft LDPE material, our ampoules provide safe, convenient dosing for patients. Whether you need single doses starting at 0,25 ml or closable multi-doses up to 5 ml, we’ve got you covered.

Up to 33,300 ampoules per hour
Single or Multi-Dose
Flexible in geometry, e.g. ampoules can be directly inserted into inhalation devices

1 - Own a Machine

Invest in your own Rommelag bottelpack BFS machine for maximum control, output rates up to 33,000 units/hour, the lowest possible cost per unit, and format changes in under two hours. We support you with setup, training, and documentation from the first concept to routine production.

2 - Leverage Our Pharma CDMO Services

Start quickly without upfront equipment investment. Our high-output BFS lines, GMP and biosafety level 2 (BSL-2) certified facilities, and experienced operators are ideal for accelerating market entry, handling demand peaks, or testing new formulations.
We provide development support, lab and pilot batches, and registration support, including extractables and leachables studies.

3 - The Hybrid Path

Start lean with our CDMO services. Once your product proves successful, transition seamlessly to in-house BFS production with full technology transfer, training, and process validation — ensuring a smooth, low-risk scale-up.

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Let’s Build Your BFS Advantage

Discover how our BFS technology can make your pharma packaging safer, simpler, and more cost-effective.

In a complimentary strategy session, our experts will work with you to:

Tailor the optimal BFS solution to your product's unique requirements.
Ensure compliance with EU GMP Annex 1, FDA, EMA, and other global standards.
Identify the best adoption path — turnkey machine ownership, CDMO, or the hybrid model
Calculate your long-term ROI and Total Cost of Ownership (TCO) to demonstrate the clear economic advantages of BFS.