Pharmaceutical Filling Machines using BFS

Whether you need to fill liquid or semi-solid pharmaceutical products, require sterile single- or multi-dose containers, or have special requirements like Luer-Lock compatibility, Rommelag’s pharmaceutical filling machines—powered by our versatile Blow-Fill-Seal (BFS) technology—are designed to meet your needs. Featuring a fully automated process, our aseptic filling machines ensure exceptional sterility, reliability, and efficiency—setting the standard for pharmaceutical filling.

Most Advanced Aseptic Filling Technology

Rommelag’s pharmaceutical filling machines leverage BFS technology, which is widely recognized as one of the most advanced aseptic filling technologies, effectively eliminating contamination risks.

Regulatory Compliance

Our bottelpack filling systems comply with the pharmaceutical industry's strictest standards, including Annex 1 of the EU GMP guidelines, and meet regulatory requirements from leading authorities such as EMA, FDA, Anvisa, and Abrasp.

Efficiency through Automated Filling Process

Our pharmaceutical filling machines automate the entire process—from container creation to filling and sealing—delivering high output, precision, and reduced error rates.

Flexible Container Design

With BFS technology, our filling systems offer unparalleled flexibility, enabling single-dose, multi-dose, and specialized container designs like Luer-Lock systems to meet diverse pharmaceutical applications.

Excellent Barrier Properties

With our multilayer BFS containers, we achieve excellent barrier properties to protect sensitive pharmaceuticals from environmental factors.

60+ Years of Proven Reliability

For over 60 years, our bottelpack machines have set the industry benchmark for reliability. Many systems have operated consistently since their installation decades ago, underscoring their durability and long-term value.

Show more

Ophthalmics

Sterile Blow-Fill-Seal ampoules made of high-quality, recyclable low-density polyethylene (LDPE) are the ideal primary packaging for ophthalmic products, suitable for both single and multiple use. They meet the highest standards in user-friendly handling, format flexibility, product protection, and comply with regulatory requirements such as USP <771>.

Unit-Dose (Typically 0.1-1ml)

Up to 33,300 ampoules per hour
Preservative-free
Easy-to-open twist-off cap
Easy to dispense

Multi-Dose (Typically 1-15ml)

Up to 12,000 ampoules per hour
With or without preservatives
Closable, tamper-proof closure

Injections

Our recyclable LDPE or polypropylene (PP) ampoules are engineered explicitly for small-volume injectables ranging from 1 to 20 ml. They enable filling even demanding pharmaceutical products with sensitivities to heat, light, or oxygen and fulfill regulatory requirements such as USP <790> and <1790>.

Up to 33,300 vented or 20,000 calibrated ampoules per hour
Luer connection for easy and safe use
Calibrated Luer ampoules collapse during the withdrawal process with the syringe, preventing air ingress and contamination.
Terminally sterilizable

Infusions

The unbreakable, lightweight, and terminally sterilizable BFS infusion bottles are the superior packaging choice for infusion products. They can be vented or unvented and feature an integrated suspension device for versatile use.

Up to 10,000 bottles per hour
Various container geometries in the 50-1000 ml range
Optimized for effective product withdrawal even without ventilation due to the collapsing design of the infusion bottle
Product withdrawal through caps with an infusion port (Euro head) or nipple head.

Inhalation Solutions

Pharmaceutical products used in inhalers or nebulizers are safely protected in sterile BFS ampoules. With a user-friendly twist-off cap and soft LDPE material, our ampoules provide safe, convenient dosing for patients. Whether you need single doses starting at 0,25 ml or closable multi-doses up to 5 ml, we’ve got you covered.

Up to 33,300 ampoules per hour
Single or Multi-Dose
Flexible in geometry, e.g. ampoules can be directly inserted into inhalation devices

bild-cta-platzhalter

bild-cta-platzhalter

BFS Produkt-Check Pharma

Möchten Sie etwas tiefer einsteigen und herausfinden, ob BFS für Ihr pharmazeutisches Produkt geeignet ist? Laden Sie unseren umfassenden BFS-Produktcheck herunter, um die Kompatibilität mit Ihren spezifischen Anforderungen zu prüfen.

Rendering einer bottelpack Anlage bp550

bottelpack

Aseptic Filling Machines That Fit Your Pharma Needs

Rommelag’s aseptic filling machines are engineered to achieve maximum efficiency in pharmaceutical production. With output rates of up to 33,000 units per hour and cost-effective polymer processing, they deliver impressively low unit costs. Their compact design reduces cleanroom and infrastructure requirements, while fast format changes in under two hours offer unmatched flexibility in dynamic markets.

Explore Filling Machine Portfolio

cdmo-packmittelentwickung

cdmo

Pharma CDMO Services

Are you looking to explore BFS technology without upfront investment? Do you need to manage production peaks or bring complex formulations to market quickly?

Rommelag’s CDMO services provide direct access to our high-output aseptic filling machines, a complete GMP environment, specially trained personnel, and biopharma-ready infrastructure, including BSL-2-certified capacities.

With over two million containers filled daily and decades of experience in pharmaceutical manufacturing, we help you move fast while meeting the highest safety and quality standards.

Explore CDMO Services

At Rommelag, we do more than manufacture industry-leading filling machines—we partner with you to bring your pharmaceutical products to life. As both a pioneering filling machine manufacturer and a trusted contract filler, we offer seamless, end-to-end solutions that support your needs at every stage of product development. Whether you're looking for a bottelpack filling machine or leverage our extensive contract filling and product development services (CDMO), Rommelag stands ready as your one-stop partner for success.

bild-cta-v2

Your Strategic Advantage in Pharmaceutical Filling

As the inventor and global leader in Blow-Fill-Seal technology, Rommelag brings unmatched expertise and decades of experience in pharmaceutical manufacturing.

In a complimentary strategy session, our senior experts will collaborate with you to build a business case and technical roadmap. We will guide you step-by-step to:

Tailor the optimal BFS system for your drug product's unique requirements.
Ensure full compliance with the latest regulatory standards, including EU GMP Annex 1 and FDA guidelines.
Map the ideal integration path for your business model — from turnkey machine ownership to our full CDMO services.
Calculate your long-term and Total Cost of Ownership () to demonstrate the clear economic advantages of BFS.