2,000+ bottelpack machines installed worldwide

Aseptic filling machines

bottelpack machines use Blow-Fill-Seal (BFS) to form, fill and seal ampoules and bottles for pharmaceutical liquids in one closed, automated process.

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4 series · large-volume bottles

Bottle filling machines

For infusion solutions, wound irrigation solutions and other large-volume parenterals.

bp 3211 mold
Data sheet
bp 3602 molds
Data sheetView machine
bp 3644 molds
Data sheet
bp 700 Seriesbp 710, 730 and 750
Data sheetView machine
Containers and output
Filling volume
100–1,000 ml
100–1,000 ml
50–2,000 ml
100–1,000 ml
Output
1,350–2,570 bottles/h
2,700–5,140 bottles/h
1,800–9,200 bottles/h
1,400–6,400 bottles/h
Plastic
LDPE, PP
LDPE, PP
LDPE
LDPE, PP
Cleanroom
Room size
100 m²12 × 8.3 m
149 m²15.2 × 9.8 m
240 m²21.8 × 11 m
156 m²10 × 15.6 m
Classified area incl. access to aseptic cabinet
56 m²
88 m²
154 m²
76 m²
Room height
4 m
4 m
5 m
3.5 m
bottelpack bp 321

bp 321

1 mold

Data sheet

Containers and output

Filling volume
100–1,000 ml
Output
1,350–2,570 bottles/h
Plastic
LDPE, PP

Cleanroom

Room size
100 m²12 × 8.3 m
Classified area incl. access to aseptic cabinet
56 m²
Room height
4 m
bottelpack bp 360

bp 360

2 molds

Data sheetView machine

Containers and output

Filling volume
100–1,000 ml
Output
2,700–5,140 bottles/h
Plastic
LDPE, PP

Cleanroom

Room size
149 m²15.2 × 9.8 m
Classified area incl. access to aseptic cabinet
88 m²
Room height
4 m
bottelpack bp 364

bp 364

4 molds

Data sheet

Containers and output

Filling volume
50–2,000 ml
Output
1,800–9,200 bottles/h
Plastic
LDPE

Cleanroom

Room size
240 m²21.8 × 11 m
Classified area incl. access to aseptic cabinet
154 m²
Room height
5 m
bottelpack bp 700 Series

bp 700 Series

bp 710, 730 and 750

Data sheetView machine

Containers and output

Filling volume
100–1,000 ml
Output
1,400–6,400 bottles/h
Plastic
LDPE, PP

Cleanroom

Room size
156 m²10 × 15.6 m
Classified area incl. access to aseptic cabinet
76 m²
Room height
3.5 m

Output range from the largest to the smallest container listed in the data sheet. Actual output depends on the plastic, the shape and weight of the bottle and the filling liquid. Room size, room height and classified area are the recommended cleanroom dimensions from the data sheets. Actual dimensions may vary slightly.

Data sheet

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2 series · up to 20 ml

Ampoule filling machines

For ophthalmics, inhalation solutions and injectables with smaller filling volumes.

bp 46015, 18 or 20 molds
Data sheet
500 Seriesbp 530 and bp 550
Data sheet
Containers and output
Format concept
Single formatHigh output, longer format change
Multiple formatsFast format change
Filling volume
0.2–10 ml
0.1–20 ml
Output
15,000–31,000 ampoules/hmax. with Performance Upgrade
7,200–12,960 ampoules/h
Plastic
LDPE, PP
LDPE, PP
Cleanroom
Room size
48 m²8 × 6 m
38 m²6.3 × approx. 6.1 m
Classified area incl. access to aseptic cabinet
20 m²
9 m²2.3 × 3.95 m
Room height
4.5 m
3.0 m
bottelpack bp 460-15

bp 460

15, 18 or 20 molds

Data sheet

Containers and output

Format concept
Single formatHigh output, longer format change
Filling volume
0.2–10 ml
Output
15,000–31,000 ampoules/hmax. with Performance Upgrade
Plastic
LDPE, PP

Cleanroom

Room size
48 m²8 × 6 m
Classified area incl. access to aseptic cabinet
20 m²
Room height
4.5 m
bottelpack bp 530

500 Series

bp 530 and bp 550

Data sheet

Containers and output

Format concept
Multiple formatsFast format change
Filling volume
0.1–20 ml
Output
7,200–12,960 ampoules/h
Plastic
LDPE, PP

Cleanroom

Room size
38 m²6.3 × approx. 6.1 m
Classified area incl. access to aseptic cabinet
9 m²2.3 × 3.95 m
Room height
3.0 m

Output range from the largest to the smallest container listed in the data sheet. Actual output depends on the plastic, the container design and the filling liquid. Room size, room height and classified area are the recommended cleanroom dimensions from the data sheets. Actual dimensions may vary slightly.

Data sheet

Fill in the form and we will email you the data sheet.

What is BFS

How Blow-Fill-Seal works

  1. Blow

    Sterile polymer resin is extruded into a mold to form the container.

  2. Fill

    The container is filled with the sterile product immediately.

  3. Seal

    The container is hermetically sealed, with no exposure to the environment.

Sterile polymer resin is extruded into a mold to form the container.

Learn more about BFS technologycoolBFS and container materials

Benefits

Why manufacturers trust bottelpack

Inventor and global market leader

more than

60years

of Blow-Fill-Seal, the technology Rommelag invented. Today, Rommelag serves customers in over 80 countries.

  1. 1960First BFS prototype, compact enough for a freight elevator
  2. 1985Closed parison technology, introduced with the bp 460
  3. 2010World’s first BFS production facility at Biosafety Level 2, for biologics
  4. 2023bottelpack 500 Series launched with the bp 530
  5. 2026bottelpack 700 platform launched
  6. TodayMore than 2,000 bottelpack machines in use worldwide

Sustainable production

up to

−80%

production waste on the 500 Series, with up to 75% less energy at the same output

bottelpack 500 Series with punch and aseptic unit

High output

up to

37,500

ampoules per hour on the bp 460-20 with Performance Upgrade

bottelpack bp 460-20

For existing cleanrooms

about

9m²

classified area for a 500 Series machine, small enough for most existing cleanrooms.

Classified areaabout 9 m² Recommended roomabout 38 m²

Built to last

some machines run for more than

30years

at customer sites. Rommelag services every bottelpack machine it has ever built, regardless of its age.

Fast changeovers

about

15min

to change the filling volume on the 500 Series. A complete format change takes under 2 hours.

Why Rommelag

From the inventor of Blow-Fill-Seal

Rommelag combines bottelpack filling systems with product development support, contract filling and lifecycle services.

60+years of BFS experience
2,000+bottelpack machines installed
80+countries served

Personal contact

Talk to your contact for new machines

Select your country. Your request goes to the person responsible for new machines there.

FAQs

Frequently asked questions

What is the difference between a Blow-Fill-Seal machine and a standard vial filling machine?

A vial filling line handles containers that already exist: vials arrive pre-formed and are washed, sterilized, filled, stoppered and capped at separate stations. A bottelpack machine forms the container from plastic granulate, fills and seals it within the same machine and the same process cycle, so there is no separate container supply, no vial washing and no stoppering station to qualify.

What container formats can a Rommelag aseptic filling machine produce?

Rommelag's bp series covers ampoule filling up to the bp 550 and bottle filling from the bp 321 up to the bp 700 Series, producing formats from single-dose ampoules and bellows containers to larger bottles, all with functional closures such as Luer-Fit, Luer-Lock, twist-off, or applicator caps. Because the container is formed as part of the process, Rommelag can also develop custom container geometries for a specific product or dosing need rather than being limited to a catalog of pre-manufactured vial sizes.

How much cleanroom space does a Rommelag aseptic filling line actually need?

Based on the recommended cleanroom dimensions in the data sheets, the classified area ranges from about 9 m² for a bottelpack 500 Series ampoule line to about 154 m² for a bp 364 bottle line. The aseptic protection comes from the closed process itself rather than from the surrounding room classification. That's a meaningful difference for manufacturers planning a new filling line, because cleanroom construction and qualification is typically one of the largest cost and time factors in setting up aseptic production, and a smaller required footprint also leaves more flexibility for later capacity expansion.

How fast can a Rommelag BFS machine switch between different container formats?

On the bottelpack 500 Series and the bp 700 Series, a complete format changeover takes less than two hours, because the mold sets and filling parameters are designed to be swapped without a full line rebuild. The bp 460 is built for high output in a single format, so its format changes take longer. For manufacturers producing multiple products or container sizes on the same line, that changeover speed directly affects how many batches can be run per week and how much idle time a facility has to plan around.