The many applications of blow-fill-seal technology

The many applications of blow-fill-seal technology

bottelpack by Rommelag is a range of advanced aseptic manufacturing machines that blow mold, fill, and seal containers in a continuous, automated process known as blow-fill-seal.

BFS technology greatly reduces human intervention in the packaging process, thus minimizing the risk of physical and microbial contamination. With high sterility, precision dosing, and cost-effective production, BFS is an indispensable technology for packaging liquids and semi-solids in pharmaceutical, cosmetic, nutraceutical, and household chemical applications.

Blow-fill-seal technology is most common for liquid pharmaceutical products, used to form and fill containers ranging from small ophthalmic ampoules to large containers of IV solution. But due to its production efficiency and virtually limitless array of custom container designs, BFS technology is increasingly finding applications in many other sectors, from cleaning agents, to skin care products, to functional foods.

advantages of aseptic filling with blow fill seal

Bottelpack vs conventional filling systems

Blow-fill-seal machines by Rommelag offer a number of advantages over conventional multi-step filling lines:

  • Automated, continuous process removes human element, greatly reducing risk of sterility failures
  • Minimizes machinery footprint and eliminates costly processes of container inventory, cleaning, and sterilizing, as well as separate filling, capping, and transport operations
  • Any container you can dream: canisters, bottles, tubes, ampoules, drop bottles, bellows, and portion packaging with filling volumes range from 0.04 ml to 10 liters
  • Output volumes up to 34,000 pieces per hour
  • A safe, flexible, and shatterproof alternative to glass containers

PHARMACEUTICAL APPLICATIONS OF BFS

Aseptic packaging for ophthalmic solutions via Blow-Fill-Seal

BFS for ophthalmic solutions

Blow-fill-seal not only improves the sterility and cost-effectiveness of eye drop manufacturing, but also enables preservative-free formulations and user-friendly packaging

• Easy-to-squeeze containers
• Precision dosing
• Wide selection of closures including tamper evidence

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BFS FOR INHALANT SOLUTIONS

With blow-fill-seal, nebulizer solutions and other respiratory care products are aseptically packaged into single-dose containers with a distinctive lightweight design.

• Fill volumes ranging from 1 to 5ml
• Easily recyclable mono-material LDPE or PP
• Custom container designs

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Aseptic packaging for sterile injectables via Blow-Fill-Seal

BFS for parenterals

From small-volume injectables to large-volume IV drip solutions, bottelpack blow-fill-seal machines offer unrivaled unit production costs and innovative container designs for parenteral manufacturing.

• Needleless withdrawal and fast administration
• Wide range of fill volumes and capacities
• Lightweight, transparent, shatterproof, and easy to store

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Aseptic packaging for vaccine manufacturing via blow-fill-seal

BFS for biotech and vaccines

Blow-fill-seal technology enables the rapid and ultra low-cost production of prefilled syringes, eliminating the need for glass vials, which are often sources of glass particulate or cross contamination.

• Cool BFS® for temperature-sensitive ingredients
• Biosafety Level 2
• Minimal cold storage volume

More pharmaceutical applications of BFS

bottelpack is used to aseptically package diverse pharmaceutical products: liquid solutions, creams, oinments, and gels.

  • Cool BFS® for heat-sensitive applications
  • Single- or multi-layer pharmaceutical packaging
  • Unit-dose or multi-dose containers
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Other applications of BFS

BFS for cosmetics and skincare

Blow-fill-seal creates attractive, user-friendly, packaging for cosmetic creams and serums.

  • Hyaluronic acid
  • Pheromone perfumes
  • Anti-aging serums
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BFS FOR NUTRACEUTICALS AND FUNCTIONAL FOODS

Blow-fill-seal offers a high degree of container design flexibility for packaging performance foods.

  • Hang-over shots
  • Beauty drinks
  • Electrolyte drinks
  • Vitamin & mineral drinks
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BFS FOR HOUSEHOLD CHEMICALS

From liquids to semi-solids to difficult-to-handle pastes, blow-fill-seal creates containers with easy squeezability and controlled flow.

  • Super glue
  • Fish tank care products
  • Machine and engine oil
  • Detergents
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BFS and digitalization

Pharma 4.0

The Rommelag Pharma Platform takes your bottelpack machines into the next generation of pharmaceutical manufacturing.

  • Open data access for archiving and operation
  • Safe API integration for increased monitoring and maintenance
  • Increased value creation for the entire life cycle
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Don’t see your product here?

BFS is often the safer, more flexible, and more cost-effective option for aseptically filling and packaging liquid and semi-solid products. If you are wondering whether bottelpack is right for your product, we are happy to offer detailed consultations and perform trials on our testing equipment.

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